{"id":3383,"date":"2022-03-27T08:02:13","date_gmt":"2022-03-27T07:02:13","guid":{"rendered":"https:\/\/biohackbase.com\/index.php\/2022\/03\/27\/brain-boosting-methylene-blue-benefits-dosing-side-effects\/"},"modified":"2022-03-27T08:02:13","modified_gmt":"2022-03-27T07:02:13","slug":"brain-boosting-methylene-blue-benefits-dosing-side-effects","status":"publish","type":"post","link":"https:\/\/biohackbase.com\/index.php\/2022\/03\/27\/brain-boosting-methylene-blue-benefits-dosing-side-effects\/","title":{"rendered":"&quot;Brain Boosting Methylene Blue&quot; Benefits, Dosing, Side Effects"},"content":{"rendered":"<p><iframe loading=\"lazy\"  width=\"580\" height=\"385\" src=\"https:\/\/www.youtube.com\/embed\/toAHzvWY99g\" frameborder=\"0\" allowfullscreen><\/iframe><br \/>\n<br \/>&#8220;Brain Boosting Methylene Blue&#8221; Benefits, Dosing, Side Effects<\/p>\n<p> \ud83d\udd34 DON&#8217;T CLICK THIS LINK \u2014\u2014\u2014\u2014\u27a2   <a href=\"https:\/\/bit.ly\/2E9EtPt\" target=\"_blank\" rel=\"noopener\">https:\/\/bit.ly\/2E9EtPt<\/a>  \ud83d\udd34 <\/p>\n<p>____________Timestamp\/Topics of Interest____________<br \/>\n@0:00 Intro<br \/>\n@1:05 &#8220;Brain Boosting Methylene Blue&#8221; Dr. Michael Moeller, ND<br \/>\n@2:12 Mechanism of Action<br \/>\n-Methemoglobinemia &#8211; Fe+2 becomes oxidized to Fe+3 producing methemoglobin. Methylene Blue reduces back.<br \/>\n-Combats free radicals = antioxidant.<br \/>\n-Antiseptic before penicillin.<br \/>\n-Increases BP = inhibits nitric oxide and guanylate cyclase, thus decreasing C-GMP and vascular smooth muscle relaxation.<br \/>\n-Reduce blood-brain barrier permeability &#8211; reduces N.O. and neuro-inflammation<br \/>\n-Nootropic \/ Biohacking &#8211; Mitochondria and Oxygen<br \/>\n@4:33 Mechanism of Action For Biohacking<br \/>\n-Nootropic \/ Biohacking<br \/>\n-Increase mitochondrial function (complex IV by 30%)<br \/>\n-Enhances cellular oxygen consumption by 37-70%<br \/>\n-Glucose uptake\/use = increase ATP<br \/>\n-Neuroprotective, Improves Memory, &#038; Reaction Time<br \/>\n-Delays and reverses senescence<br \/>\n-Antidepressant and Anxiolytic<br \/>\n-Inhibits N.O. tho? MAOi<br \/>\n@8:30 Indications<br \/>\nMethemoglobinemia &#8211; Carry less oxygen turns you blue.<br \/>\nFrom drugs\/toxicity and CO2<br \/>\nIfosfamide<br \/>\nShock\/Low Blood Pressure<br \/>\nDyes for surgery<br \/>\nFish Tanks<br \/>\nPreviously: Cyanide poisoning\/UTIs<br \/>\nMalaria<br \/>\nBi-polarAlzheimers\/Dementia<br \/>\nCancer<br \/>\nC-Virus<br \/>\nNeutralizes heparin<br \/>\nPriapism<br \/>\n@11:58 Contraindications<br \/>\nPsych Meds\/Antidepressants<br \/>\nSSRIs SNRIs<br \/>\nMAOi<br \/>\nSerotonin Syndrome FATAL!!!!!!<br \/>\nG6PD<br \/>\nVital Signs<br \/>\nLiver\/Kidney pathology<br \/>\nHeinz body anemia<br \/>\n@13:30 Side Effects<br \/>\nTurns your urine green\/blue!<br \/>\nSerotonin syndrome<br \/>\nAllergic or anaphylaxis<br \/>\nG6PD = Hemolysis<br \/>\nSweating, Hot\/cold<br \/>\nDizziness<br \/>\nLong-term studies?<br \/>\n@15:25 Dose and Administration<br \/>\nOral  &#8211; 4-250mg<br \/>\nIV &#8211; 1-2mg per kg<br \/>\nOver 5-30 minutes<br \/>\nHalf-life 5-7 hours<br \/>\nMalaria &#8211; 36-72mg\/kg over 3 days? Oral 390mg twice a day<br \/>\nAlzheimer&#8217;s\/UTI prevention &#8211; 65mg three times daily (interesting fact UTI\/Neuro)<br \/>\nSafe under 2mg\/kg<br \/>\nFatal over 5mg\/kg serotonin syndrome (COMT, MTFR, Cytochromes P450, Gilberts)<br \/>\n@17:11 Hormetic Effect<br \/>\nMore is not better<br \/>\nA lower dose of 0.05 mg kg\u22121 MB administered immediately following the training also had a memory-enhancing effect that approached significance.<br \/>\nInterestingly, a 5 mg kg\u22121 MB dose given immediately following training did not differ from a saline-treated control condition.<br \/>\nHowever, a 50 mg kg\u22121 MB dose given 15 min before training produced amnesia<br \/>\n@18:25 Sources<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17928358\/#:\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/17928358\/#:<\/a>~:text=MB%20delays%20senescence%20at%20nM,caused%20by%20H2O2%20or%20cadmium.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3087269\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3087269\/<\/a><br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK350467\/#:\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK350467\/#:<\/a>~:text=Methylene%20blue%20is%20a%20synthetic%20substance%20and%20does%20not%20occur%20naturally.<br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/methylene-blue\" target=\"_blank\" rel=\"noopener\">https:\/\/www.sciencedirect.com\/topics\/neuroscience\/methylene-blue<\/a><br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0079612321001552\" target=\"_blank\" rel=\"noopener\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0079612321001552<\/a><br \/>\n<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s40263-019-00641-3\" target=\"_blank\" rel=\"noopener\">https:\/\/link.springer.com\/article\/10.1007\/s40263-019-00641-3<\/a><br \/>\n<a href=\"https:\/\/en.wikipedia.org\/wiki\/Methylene_blue#:\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Methylene_blue#:<\/a>~:text=Methylene%20blue%20is%20a%20thiazine,are%20symptoms%20despite%20oxygen%20therapy.<br \/>\n<a href=\"https:\/\/www.drugs.com\/mtm\/methylene-blue-injection.html\" target=\"_blank\" rel=\"noopener\">https:\/\/www.drugs.com\/mtm\/methylene-blue-injection.html<\/a><br \/>\n<a href=\"https:\/\/my.clevelandclinic.org\/health\/drugs\/20881-methylene-blue-injection\" target=\"_blank\" rel=\"noopener\">https:\/\/my.clevelandclinic.org\/health\/drugs\/20881-methylene-blue-injection<\/a><br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34019535\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34019535\/<\/a><br \/>\n<a href=\"https:\/\/riviste.fupress.net\/index.php\/subs\/article\/view\/888\" target=\"_blank\" rel=\"noopener\">https:\/\/riviste.fupress.net\/index.php\/subs\/article\/view\/888<\/a><br \/>\n<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2015.00179\/full\" target=\"_blank\" rel=\"noopener\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2015.00179\/full<\/a><br \/>\n<a href=\"http:\/\/www.biomed.cas.cz\/physiolres\/pdf\/49%\" target=\"_blank\" rel=\"noopener\">http:\/\/www.biomed.cas.cz\/physiolres\/pdf\/49%<\/a>20Suppl%201\/49_S27.pdf<br \/>\n<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01836094\" target=\"_blank\" rel=\"noopener\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01836094<\/a><br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/labs\/pmc\/articles\/PMC3265679\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/labs\/pmc\/articles\/PMC3265679\/<\/a><br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/labs\/pmc\/articles\/PMC2867617\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/labs\/pmc\/articles\/PMC2867617\/<\/a><\/p>\n<p>\u25b6\ufe0fSponsors\u25c0\ufe0f<br \/>\n\u27a2\ud83e\uddea<a href=\"https:\/\/trylgc.com\/DrMoe\" target=\"_blank\" rel=\"noopener\">https:\/\/trylgc.com\/DrMoe<\/a>  \ud83d\udcb8 \ud83d\udcb8 \ud83d\udcb8 Get 20% off with code DRMOE \ud83d\udcb8 \ud83d\udcb8 \ud83d\udcb8<br \/>\n\u27a2\ud83d\udc8a<a href=\"https:\/\/bit.ly\/2Xuzp5D\" target=\"_blank\" rel=\"noopener\">https:\/\/bit.ly\/2Xuzp5D<\/a><\/p>\n<p>\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014 Lets Connect\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014\u2014<br \/>\n\ud83d\udcfa Click here to Subscribe: <a href=\"https:\/\/www.youtube.com\/channel\/UCOaFjrkfRyKWj4ZjBRXdm8Q?sub_confirmation=1\" target=\"_blank\" rel=\"noopener\">https:\/\/www.youtube.com\/channel\/UCOaFjrkfRyKWj4ZjBRXdm8Q?sub_confirmation=1<\/a><br \/>\n\ud83d\udcf2 Instagram: <a href=\"https:\/\/www.instagram.com\/dr.michaelmoeller\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.instagram.com\/dr.michaelmoeller\/<\/a><\/p>\n<p>\ud83d\udd34==========\u26a0\ufe0f Full Disclaimer\u26a0\ufe0f==========\ud83d\udd34<br \/>\nThe information provided in this video is for entertainment purposes only and IS NOT MEDICAL ADVICE. If you have questions about your health contact a medical professional.This content is strictly the opinion of Dr. Michael Moeller and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Michael Moeller nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.<br \/>\n#MethyleneBlue<br \/>\n#Nootropics<br \/>\n#Biohacking<br \/>\n<br \/><a href=\"https:\/\/www.youtube.com\/watch?v=toAHzvWY99g\">source<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Brain Boosting Methylene Blue&#8221; Benefits, Dosing, Side Effects \ud83d\udd34 DON&#8217;T CLICK THIS LINK \u2014\u2014\u2014\u2014\u27a2 https:\/\/bit.ly\/2E9EtPt \ud83d\udd34 ____________Timestamp\/Topics of Interest____________ @0:00<\/p>\n","protected":false},"author":1,"featured_media":3384,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[8,6,5,4,10,11,9,7,689,920],"class_list":["post-3383","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bio-hacking-bio-engineering-videos","tag-bio-hack","tag-bioengineering","tag-biohacker","tag-biohacking","tag-biohacking-crispr","tag-biohacking-diet","tag-biohacking-kit","tag-biological-engineering","tag-genome","tag-genome-editing"],"_links":{"self":[{"href":"https:\/\/biohackbase.com\/index.php\/wp-json\/wp\/v2\/posts\/3383","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biohackbase.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biohackbase.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biohackbase.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biohackbase.com\/index.php\/wp-json\/wp\/v2\/comments?post=3383"}],"version-history":[{"count":0,"href":"https:\/\/biohackbase.com\/index.php\/wp-json\/wp\/v2\/posts\/3383\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biohackbase.com\/index.php\/wp-json\/wp\/v2\/media\/3384"}],"wp:attachment":[{"href":"https:\/\/biohackbase.com\/index.php\/wp-json\/wp\/v2\/media?parent=3383"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biohackbase.com\/index.php\/wp-json\/wp\/v2\/categories?post=3383"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biohackbase.com\/index.php\/wp-json\/wp\/v2\/tags?post=3383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}