"Brain Boosting Methylene Blue" Benefits, Dosing, Side Effects
“Brain Boosting Methylene Blue” Benefits, Dosing, Side Effects
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____________Timestamp/Topics of Interest____________
@0:00 Intro
@1:05 “Brain Boosting Methylene Blue” Dr. Michael Moeller, ND
@2:12 Mechanism of Action
-Methemoglobinemia – Fe+2 becomes oxidized to Fe+3 producing methemoglobin. Methylene Blue reduces back.
-Combats free radicals = antioxidant.
-Antiseptic before penicillin.
-Increases BP = inhibits nitric oxide and guanylate cyclase, thus decreasing C-GMP and vascular smooth muscle relaxation.
-Reduce blood-brain barrier permeability – reduces N.O. and neuro-inflammation
-Nootropic / Biohacking – Mitochondria and Oxygen
@4:33 Mechanism of Action For Biohacking
-Nootropic / Biohacking
-Increase mitochondrial function (complex IV by 30%)
-Enhances cellular oxygen consumption by 37-70%
-Glucose uptake/use = increase ATP
-Neuroprotective, Improves Memory, & Reaction Time
-Delays and reverses senescence
-Antidepressant and Anxiolytic
-Inhibits N.O. tho? MAOi
@8:30 Indications
Methemoglobinemia – Carry less oxygen turns you blue.
From drugs/toxicity and CO2
Ifosfamide
Shock/Low Blood Pressure
Dyes for surgery
Fish Tanks
Previously: Cyanide poisoning/UTIs
Malaria
Bi-polarAlzheimers/Dementia
Cancer
C-Virus
Neutralizes heparin
Priapism
@11:58 Contraindications
Psych Meds/Antidepressants
SSRIs SNRIs
MAOi
Serotonin Syndrome FATAL!!!!!!
G6PD
Vital Signs
Liver/Kidney pathology
Heinz body anemia
@13:30 Side Effects
Turns your urine green/blue!
Serotonin syndrome
Allergic or anaphylaxis
G6PD = Hemolysis
Sweating, Hot/cold
Dizziness
Long-term studies?
@15:25 Dose and Administration
Oral – 4-250mg
IV – 1-2mg per kg
Over 5-30 minutes
Half-life 5-7 hours
Malaria – 36-72mg/kg over 3 days? Oral 390mg twice a day
Alzheimer’s/UTI prevention – 65mg three times daily (interesting fact UTI/Neuro)
Safe under 2mg/kg
Fatal over 5mg/kg serotonin syndrome (COMT, MTFR, Cytochromes P450, Gilberts)
@17:11 Hormetic Effect
More is not better
A lower dose of 0.05 mg kg−1 MB administered immediately following the training also had a memory-enhancing effect that approached significance.
Interestingly, a 5 mg kg−1 MB dose given immediately following training did not differ from a saline-treated control condition.
However, a 50 mg kg−1 MB dose given 15 min before training produced amnesia
@18:25 Sources
https://pubmed.ncbi.nlm.nih.gov/17928358/#:~:text=MB%20delays%20senescence%20at%20nM,caused%20by%20H2O2%20or%20cadmium.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087269/
https://www.ncbi.nlm.nih.gov/books/NBK350467/#:~:text=Methylene%20blue%20is%20a%20synthetic%20substance%20and%20does%20not%20occur%20naturally.
https://www.sciencedirect.com/topics/neuroscience/methylene-blue
https://www.sciencedirect.com/science/article/abs/pii/S0079612321001552
https://link.springer.com/article/10.1007/s40263-019-00641-3
https://en.wikipedia.org/wiki/Methylene_blue#:~:text=Methylene%20blue%20is%20a%20thiazine,are%20symptoms%20despite%20oxygen%20therapy.
https://www.drugs.com/mtm/methylene-blue-injection.html
https://my.clevelandclinic.org/health/drugs/20881-methylene-blue-injection
https://pubmed.ncbi.nlm.nih.gov/34019535/
https://riviste.fupress.net/index.php/subs/article/view/888
https://www.frontiersin.org/articles/10.3389/fncel.2015.00179/full
http://www.biomed.cas.cz/physiolres/pdf/49%20Suppl%201/49_S27.pdf
https://clinicaltrials.gov/ct2/show/NCT01836094
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3265679/
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2867617/
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🔴==========⚠️ Full Disclaimer⚠️==========🔴
The information provided in this video is for entertainment purposes only and IS NOT MEDICAL ADVICE. If you have questions about your health contact a medical professional.This content is strictly the opinion of Dr. Michael Moeller and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Michael Moeller nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.
#MethyleneBlue
#Nootropics
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